MovDisordV3, Main, Exploration, bibRecord, 003108

Apolipoprotein E ε4 allele is associated with parkinson disease risk in a mexican mestizo population

Identifieur interne : 003108 ( Main/Exploration ); précédent : 003107; suivant : 003109

Apolipoprotein E ε4 allele is associated with parkinson disease risk in a mexican mestizo population

Auteurs : Marisol Lopez [Mexique] ; Jorge Guerrero [Mexique] ; Petra Yescas [Mexique] ; Marie-Catherine Boll [Mexique] ; Itziar Familiar [Mexique] ; Adriana Ochoa [Mexique] ; Astrid Rasmussen [Mexique] ; Maria Elisa Alonso [Mexique]

Source :

Movement disorders [ 0885-3185 ] ; 2007.

RBID : Pascal:07-0181708

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Apolipoprotéine E, Facteur risque.

English descriptors

KwdEn :
- Apolipoprotein E, Nervous system diseases, Parkinson disease, Risk factor.

Abstract

We investigated the association between apolipoprotein E (APOE) alleles and genotypes and Parkinson disease (PD) in 229 unrelated Mexican Mestizo PD patients and 229 controls. Results showed that both APOE-E4 allele and APOE e4/e3 genotype are associated with PD (OR = 1.736, P = 0.011; OR = 1.688, P = 0.019, respectively). Mean age at onset of PD was not associated to any APOE allele or genotype, but was significantly earlier in familial PD when compared to sporadic cases (P = 0.025).

Affiliations:

Mexique

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Le document en format XML

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<author><name sortKey="Rasmussen, Astrid" sort="Rasmussen, Astrid" uniqKey="Rasmussen A" first="Astrid" last="Rasmussen">Astrid Rasmussen</name>
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<author><name sortKey="Alonso, Maria Elisa" sort="Alonso, Maria Elisa" uniqKey="Alonso M" first="Maria Elisa" last="Alonso">Maria Elisa Alonso</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurologia y Neurocirugía Manuel Velasco Sudrez</s1>
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<author><name sortKey="Lopez, Marisol" sort="Lopez, Marisol" uniqKey="Lopez M" first="Marisol" last="Lopez">Marisol Lopez</name>
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<s2>Mexico City</s2>
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<author><name sortKey="Guerrero, Jorge" sort="Guerrero, Jorge" uniqKey="Guerrero J" first="Jorge" last="Guerrero">Jorge Guerrero</name>
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<author><name sortKey="Yescas, Petra" sort="Yescas, Petra" uniqKey="Yescas P" first="Petra" last="Yescas">Petra Yescas</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurologia y Neurocirugía Manuel Velasco Sudrez</s1>
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<author><name sortKey="Boll, Marie Catherine" sort="Boll, Marie Catherine" uniqKey="Boll M" first="Marie-Catherine" last="Boll">Marie-Catherine Boll</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Division of Neurology, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suárez</s1>
<s2>Mexico City</s2>
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<sZ>4 aut.</sZ>
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<country>Mexique</country>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Familiar, Itziar" sort="Familiar, Itziar" uniqKey="Familiar I" first="Itziar" last="Familiar">Itziar Familiar</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurologia y Neurocirugía Manuel Velasco Sudrez</s1>
<s2>Mexico City</s2>
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<country>Mexique</country>
<wicri:noRegion>Mexico City</wicri:noRegion>
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</author>
<author><name sortKey="Ochoa, Adriana" sort="Ochoa, Adriana" uniqKey="Ochoa A" first="Adriana" last="Ochoa">Adriana Ochoa</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurologia y Neurocirugía Manuel Velasco Sudrez</s1>
<s2>Mexico City</s2>
<s3>MEX</s3>
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<country>Mexique</country>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rasmussen, Astrid" sort="Rasmussen, Astrid" uniqKey="Rasmussen A" first="Astrid" last="Rasmussen">Astrid Rasmussen</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurologia y Neurocirugía Manuel Velasco Sudrez</s1>
<s2>Mexico City</s2>
<s3>MEX</s3>
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<sZ>5 aut.</sZ>
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<country>Mexique</country>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alonso, Maria Elisa" sort="Alonso, Maria Elisa" uniqKey="Alonso M" first="Maria Elisa" last="Alonso">Maria Elisa Alonso</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurogenetics and Molecular Biology, Instituto Nacional de Neurologia y Neurocirugía Manuel Velasco Sudrez</s1>
<s2>Mexico City</s2>
<s3>MEX</s3>
<sZ>2 aut.</sZ>
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<country>Mexique</country>
<wicri:noRegion>Mexico City</wicri:noRegion>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apolipoprotein E</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Risk factor</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
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<front><div type="abstract" xml:lang="en">We investigated the association between apolipoprotein E (APOE) alleles and genotypes and Parkinson disease (PD) in 229 unrelated Mexican Mestizo PD patients and 229 controls. Results showed that both APOE-E4 allele and APOE e4/e3 genotype are associated with PD (OR = 1.736, P = 0.011; OR = 1.688, P = 0.019, respectively). Mean age at onset of PD was not associated to any APOE allele or genotype, but was significantly earlier in familial PD when compared to sporadic cases (P = 0.025).</div>
</front>
</TEI>
<affiliations><list><country><li>Mexique</li>
</country>
</list>
<tree><country name="Mexique"><noRegion><name sortKey="Lopez, Marisol" sort="Lopez, Marisol" uniqKey="Lopez M" first="Marisol" last="Lopez">Marisol Lopez</name>
</noRegion>
<name sortKey="Alonso, Maria Elisa" sort="Alonso, Maria Elisa" uniqKey="Alonso M" first="Maria Elisa" last="Alonso">Maria Elisa Alonso</name>
<name sortKey="Boll, Marie Catherine" sort="Boll, Marie Catherine" uniqKey="Boll M" first="Marie-Catherine" last="Boll">Marie-Catherine Boll</name>
<name sortKey="Familiar, Itziar" sort="Familiar, Itziar" uniqKey="Familiar I" first="Itziar" last="Familiar">Itziar Familiar</name>
<name sortKey="Guerrero, Jorge" sort="Guerrero, Jorge" uniqKey="Guerrero J" first="Jorge" last="Guerrero">Jorge Guerrero</name>
<name sortKey="Ochoa, Adriana" sort="Ochoa, Adriana" uniqKey="Ochoa A" first="Adriana" last="Ochoa">Adriana Ochoa</name>
<name sortKey="Rasmussen, Astrid" sort="Rasmussen, Astrid" uniqKey="Rasmussen A" first="Astrid" last="Rasmussen">Astrid Rasmussen</name>
<name sortKey="Yescas, Petra" sort="Yescas, Petra" uniqKey="Yescas P" first="Petra" last="Yescas">Petra Yescas</name>
</country>
</tree>
</affiliations>
</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Apolipoprotein E ε4 allele is associated with parkinson disease risk in a mexican mestizo population

Apolipoprotein E ε4 allele is associated with parkinson disease risk in a mexican mestizo population

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri